Name | NSC5844 |
Synonyms | RE640 RE 640 RE640 RE-640 NSC5844 RE-640 RE 640 NSC 5844 NSC-5844 NSC5844 (RE640) N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine 1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)- |
CAS | 140926-75-6 |
Molecular Formula | C20H16Cl2N4 |
Molar Mass | 383.27 |
Density | 1.431±0.06 g/cm3(Predicted) |
Boling Point | 632.6±55.0 °C(Predicted) |
Solubility | 10 mM in DMSO |
pKa | 6.61±0.50(Predicted) |
Storage Condition | -20℃ |
In vitro study | NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI 50 s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum , inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum , with IC 50 s of 17 and 27 nM, respectively. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.609 ml | 13.046 ml | 26.091 ml |
5 mM | 0.522 ml | 2.609 ml | 5.218 ml |
10 mM | 0.261 ml | 1.305 ml | 2.609 ml |
5 mM | 0.052 ml | 0.261 ml | 0.522 ml |
Biological activity | NSC5844 is a 4-aminoquinoline derivative with anti-tumor and anti-malaria activity. |
target | Parasite |
in vitro study | NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI 50 s of 7.35±0.10 μM and 14.80±0.35 μM against MDA-MB-468 and MCF-7 cells, respectively. NSC5844 (Compound 1) is cytotoxic to P. falciparum , inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of p. falciparum , with IC 50 s of 17 and 27 nM, respectively. |